Path of Exile 2 (POE2) is a highly anticipated action RPG from Grinding Gear Games, bringing a host of new features to the acclaimed Path of Exile series. In POE2, players can team up in co-op play for up to six players, embarking on an expansive new campaign that spans six acts. The game introduces over 600 monsters, 100 environments, and a staggering 100 bosses, giving players plenty of content to explore and conquer.

As you traverse POE2's vast world, you'll encounter different biomes, craft valuable items, and face off against challenging bosses. However, the journey is not without its mysteries. One such mystery involves the Azakh-kul Poison, a dangerous toxin that plagues the Slithering Dead area in the game. In this guide, we'll walk you through how to find the source of this deadly poison, allowing you to progress through the story and earn valuable rewards—perhaps even POE 2 Currency to upgrade your gear and make your character stronger.
Step-by-Step Guide: Finding the Source of the Azakh-kul Poison in POE 2
To find the source of the Azakh-kul Poison in Path of Exile 2, you'll need to navigate through the Jungle Ruins and locate the Venom Crypts. Here's a detailed breakdown of the steps to complete this objective:
Step 1: Head to the Jungle Ruins
Your journey begins in the Jungle Ruins, one of the earlier areas you'll encounter while exploring POE2's expansive world. This lush, dangerous biome is teeming with aggressive wildlife, poisonous plants, and other hazards. To find the Azakh-kul Poison's source, you'll need to venture southwest from the Jungle Ruins.
As you move through this area, be prepared to fight off a variety of enemies. Keep an eye on your map and use the minimap to orient yourself toward the correct direction. Your destination is not far from your starting point, so you won't need to travel extensively across the entire region.
Step 2: Locate the Entrance to the Venom Crypts
The next objective is to find the entrance to the Venom Crypts, which are hidden to the southwest of the Jungle Ruins. This area is essential to your progress in tracking down the poison's source, so be sure to stay focused on reaching it.
When you arrive in the area, look for the entrance near a checkpoint and waypoint. These markers are key for saving your progress and quickly returning to this location if needed. Once you locate the entrance, prepare yourself for a deeper dive into the Venom Crypts, where the Azakh-kul Poison awaits.
Step 3: Enter the Venom Crypts
Once you've found the entrance to the Venom Crypts, enter the area and begin your search for the poison's source. The Venom Crypts are a dark, eerie place filled with traps, poisonous enemies, and other dangers. As you make your way through this underground labyrinth, be on the lookout for key objects and clues that will lead you closer to your objective.
Your main focus here is to find a specific room within the crypts that contains a dead body—this is where the source of the Azakh-kul Poison is located. It's important to remember that the Venom Crypts are not just a straight path; they require some exploration. Use the game's map to help you navigate the twisting corridors and hidden chambers. Be ready for combat, as there will be a variety of hostile creatures lurking in the shadows.