Path of Exile 2 Depleted Mana Rune Guide: How to Obtain Runeseeker's Call and Maximize Its Power

Summary

The Depleted Mana Rune is one of Path of Exile 2's most intriguing endgame quest items, offering a powerful unique wand to players who can meet its demanding requirements. Dropped by Uhtred, the Stardrinker in Expedition content, this rare item must be transformed by spending 10,000 Mana before it can be exchanged for Runeseeker's Call—a unique Runic Fork with 5 sockets and 200% increased effect of socketed Runes. For players looking to optimize their endgame gear and acquire the necessary resources, POE2 Currency plays a vital role in securing this powerful weapon through trade.

What Is the Depleted Mana Rune?

The Depleted Mana Rune is a quest item introduced in the Runes of Aldur league. Its flavor text reads: "The rune hungers, an empty chasm..."—a fitting description for an item that demands an enormous sacrifice of mana to unlock its true potential.

The item drops from Uhtred, the Stardrinker, a boss encountered during the Grand Expedition endgame questline. Uhtred is located in Secluded Temple maps, which can be found in Ocean biomes. To guarantee an encounter, players should have Uhtred's Saga active in their inventory before revealing a biome with an Expedition Logbook.

Important note: The Depleted Mana Rune can only be acquired once per character. Losing or discarding the item may permanently prevent that character from obtaining Runeseeker's Call through the questline.

How to Transform the Depleted Mana Rune

Transforming the Depleted Mana Rune requires reaching a massive mana threshold: 10,000 total Mana. This is one of the most demanding stat requirements in the game and typically requires significant build investment.

Key transformation details:

Overflowed Mana counts toward the 10,000 requirement. Sources like Sacrifice of Mind or Mana Remnants can help reach this threshold.

Once you have at least 10,000 Mana, right-click the Depleted Mana Rune in your inventory.

The item transforms into an Infused Mana Rune, arcane energy churning wildly within it.

How to Obtain Runeseeker's Call

After transforming the Depleted Mana Rune into its infused form, take it to Farrow, an NPC located next to Dannig in Kingsmarch during Act 4. Farrow will exchange the Infused Mana Rune for Runeseeker's Call, a unique Runic Fork wand.

Runeseeker's Call Stats and Modifiers

The Runeseeker's Call is a Level 65 wand requiring 114 Intelligence. Its key modifiers include 5 Augment Sockets that are hidden, along with 200% increased effect of socketed Runes. The wand grants the skill The Stars Answer, and only Runes can be socketed into its slots.

The Stars Answer is a cold damage skill that causes massive rocks to fall from space for an extended period—but it costs 10,000 Mana per cast.

The 200% rune effectiveness bonus is the main draw, effectively tripling the benefits of any runes socketed into the wand. This bonus also applies to Bonded modifiers unlocked via Shaman's Wisdom of the Maji.

For players seeking even more power, Runeseeker's Call can be corrupted to obtain a 6th Augment socket among other corruption outcomes.

Build Requirements and Challenges

Reaching 10,000 Mana

The primary challenge is achieving 10,000 Mana. Most players need to completely respecialize their passive tree, prioritize intelligence and mana nodes, and rework their gear to maximize mana pool.

Several items can help reach this threshold. Everlasting Gaze, an Azure Amulet, provides 20-30% increased Mana Regeneration Rate and grants 20-30% of Maximum Mana as Extra Maximum Energy Shield. The Calibration notable passive increases maximum Mana by 4% and maximum Energy Shield by 30% when instilled on an amulet.

High Casting Cost

Even after acquiring the wand, its signature skill, The Stars Answer, costs 10,000 Mana per cast—making the weapon most suitable for mana-stacking builds that can sustain this astronomical cost.

The One-Per-Character Limitation

A critical consideration is the item's acquisition limit. The Depleted Mana Rune can only be acquired once per character. If you lose or discard the rune before completing the quest, you may not be able to obtain Runeseeker's Call through the questline on that character.

Several players have reported farming Uhtred extensively without receiving a second drop, suggesting that the quest item may not drop again after the quest is completed or the item is lost. For players who lose the item, purchasing Runeseeker's Call through trade may be the only alternative.

Final Thoughts

The Depleted Mana Rune and its reward, Runeseeker's Call, represent one of Path of Exile 2's most demanding but rewarding endgame pursuits. The journey requires defeating a rare Expedition boss, building a character capable of reaching 10,000 Mana, and committing to a unique playstyle built around astronomical mana costs.

For players who can meet these requirements, Runeseeker's Call offers a potentially best-in-slot option with its 200% rune effectiveness bonus and 5-socket design. The weapon's power scales dramatically with quality runes, making it a long-term investment worth pursuing.

Whether you're farming Uhtred for the drop or planning to acquire Runeseeker's Call through trade, having the right resources is essential for optimizing this build. For players who want to skip the extended grind and focus on perfecting their mana-stacking build, buy POE2 Currency provides a direct path to acquiring the necessary gear and materials for this powerful endgame wand.