​PoE 2 Depleted Mana Rune Guide: How to Get Runeseeker's Call and Unlock the 10,000 Mana Reward

Summary

If you have reached the endgame in Path of Exile 2, you may eventually encounter one of the most unusual boss drops in the game: the Depleted Mana Rune. Although the item appears useless at first, it can be transformed into a powerful reward by completing a demanding Mana-based challenge.

The process requires a massive 10,000 Mana investment, making it difficult for most builds to complete without major changes. However, the final reward, Runeseeker's Call, can be an extremely valuable endgame item for the right build. If your build falls short, trading for POE2 Items can help you reach the threshold and claim the reward.

How to Get the Depleted Mana Rune in PoE 2

The first step is obtaining the Depleted Mana Rune. This item drops from Uhtred, a boss encountered during the endgame Expedition content.

Because the rune comes from a specific endgame boss, acquiring one can already be challenging. Once you obtain it, however, the real work begins.

The Depleted Mana Rune must be activated by spending 10,000 Mana. This does not mean simply having 10,000 maximum Mana in your inventory or on your character. You need to create a build capable of reaching the required Mana threshold and then use the rune.

The basic process is:

1. Defeat Uhtred during endgame Expedition content.

2. Obtain the Depleted Mana Rune.

3. Build your character to reach at least 10,000 Mana.

4. Use the Depleted Mana Rune from your inventory.

5. Transform it into an Infused Mana Rune.

6. Return to Farrow and exchange the Infused Mana Rune.

7. Receive Runeseeker's Call.

How to Activate the Depleted Mana Rune

After obtaining the rune, speak with Farrow to begin the process. The item itself requires a massive Mana cost to activate.

To complete the activation, you need to reach 10,000 Mana. For most characters, this is far beyond what their normal build naturally provides. As a result, many players will need to temporarily modify their passive tree and equipment.

This may involve completely respeccing your passive skills to prioritize Mana-related bonuses. You may also need to replace several pieces of gear with items that provide additional maximum Mana.

Once your character reaches the required threshold, use the Depleted Mana Rune directly from your inventory. If you have enough Mana, the item will transform into the Infused Mana Rune.

This transformation is the key step in the entire process.

Why Reaching 10,000 Mana Is So Difficult

The main challenge is not the item interaction itself. Activating the rune is simple once you have the required resources.

The problem is that most endgame builds are not designed to reach 10,000 Mana. Players usually need to make significant sacrifices to their normal setup, including:

Respeccing large portions of the Passive Skill Tree

Replacing gear with Mana-focused equipment

Giving up damage, defenses, or other important stats

Temporarily creating a specialized Mana-stacking setup

Because of this, it is usually best to prepare the required build before attempting to activate the rune. Trying to improvise after obtaining the item can be expensive and time-consuming.

How to Get Runeseeker's Call

After transforming the Depleted Mana Rune into an Infused Mana Rune, return to Farrow.

Make sure the Infused Mana Rune is in your inventory when you speak with him. Farrow will recognize that the rune has changed and begin the next part of the interaction.

After a short conversation, he will give you Runeseeker's Call, a special Ezomyte Wand.

This is the final reward for completing the 10,000 Mana challenge.

What Makes Runeseeker's Call Special?

Runeseeker's Call is valuable because of its powerful interaction with Socketed Runes. The wand can have five or six slots, can be upgraded, and can potentially be worth a significant amount of currency depending on its quality and market demand.

Its most important effect is the ability to increase the effect of Socketed Runes by 200%.

For builds that can take advantage of powerful Rune effects, this modifier can make Runeseeker's Call an exceptional endgame weapon. The value of the item depends heavily on the Rune setup you plan to use, but the potential is high enough to make the entire Mana investment worthwhile.

The Stars Answer: The Unique Spell Reward

Runeseeker's Call also gives access to a special spell called The Stars Answer.

This is a Cold damage ability that functions somewhat similarly to Walking Calamity. When activated, massive rocks fall from the sky for an extended period of time, creating a dramatic area-of-effect attack.

The spell has an extremely unusual drawback: it always costs 10,000 Mana to cast.

That means most ordinary builds cannot use it effectively. However, characters that have already invested heavily into Mana can potentially make use of the ability.

Even when it is not the strongest option for your build, The Stars Answer is still one of the more visually impressive rewards connected to the Depleted Mana Rune.

Is the Depleted Mana Rune Worth Using?

For most players, the answer depends on their build and the value of Runeseeker's Call on the market.

The process is expensive because reaching 10,000 Mana usually requires a temporary respec and major gear changes. If your build cannot naturally support the investment, you may spend considerable resources simply to activate the rune.

However, the reward can be extremely powerful. The 200% increase to Socketed Rune effects can make Runeseeker's Call a best-in-slot or near-best-in-slot option for certain builds.

The most efficient approach is to prepare your Mana-stacking setup in advance, activate the rune, complete the exchange with Farrow, and then return to your normal build if necessary.

In short, the Depleted Mana Rune is not an item you should simply sell or ignore. If you can overcome the 10,000 Mana requirement, it can be transformed into one of the most interesting and potentially valuable rewards available through the endgame Expedition system. To hit that threshold faster, Buy Path Of Exile 2 Items and gear up quickly.